Nuclear architecture in cancer and aging-related diseases
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Dr. Lindsay Shopland investigates the contributions of nuclear architecture to gene expression in cancer and aging-related diseases. Her research focuses on the nuclear lamina, a scaffold of filaments that organizes the genome in the nucleus. Defects in the nuclear lamina impair adult stem cell populations and cause a number of severe human genetic diseases, including lipodystrophies, skeletal abnormalities, peripheral neuropathies, and the premature aging syndrome, Hutchinson Gilford progeria. The Shopland laboratory applies high-resolution 3D imaging and mouse genetics resources to investigate nuclear lamina functions in stem cells that give rise to fatty tissue and bone.
Dr. Shopland received her PhD in Biochemistry, Molecular, and Cell Biology from Cornell University, and did her postdoctoral training in Nuclear Cell Biology at the University of Massachusetts Medical School. She currently serves on the faculty of The Jackson Laboratory.
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