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In 2006 the Burgess lab reported a mouse model of Charcot-Marie-Tooth type 2D (CMT2D), an axonal peripheral neuropathy caused by mutations in glycyl tRNA synthetase (GARS). The Burgess lab has since become very involved in the development and characterization of related neuromuscular disease models, and particularly peripheral neuropathy models in mice involving tRNA synthetase genes and congenital myasthenias. Integrating our results in mouse genetics with external efforts in human genetics is a primary focus of the research and the validation of human disease genes and the generation of valid animal models of neuromuscular diseases is central to this effort.

Lunch will be provided.

Hosted by: Dr. Edward Bilsky