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 Understanding the delicate balance of forces governing helix/beta-hairpin interactions in transmembrane proteins is central to understanding membrane structure and function. These membrane interactions play an essential role in determining the structure and function of membrane proteins, and protein interactions in membranes, and thus form the basis for many vital processes. The Im research group has published novel methods and their applications that begin to address the complicated energetics and molecular mechanisms of these interactions at the atomic level. The talk will summarize these research accomplishments, and present recent on-going research activities to elucidate aforementioned questions. The talk will also briefly mention other research activities in the group, such as a web-based platform for molecular simulation, non-protein membrane simulation results, and protein translocation through the bacterial type-three secretion system.