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The quest for equity in global health remains a major challenge as new diseases threaten to erase gains in lives saved over the last few decades. Culture is a critical aspect of how we address global health. Understanding the relationship between health and culture in countries around the world can mean the difference between success and failure in promoting health and preventing diseases globally. Global health requires a multidisciplinary approach to understanding behaviors and contexts related to health. Learn about an exciting cultural model (PEN-3) that is being applied globally to health promotion, health behavior, and public health programs.